CEFTRIAXONE

 CEFTRIAXONE

JENIS

Antibakteri sefalosporin generasi ketiga

INDIKASI

-Infeksi bakteri yang parah: septikemia, meningitis, pneumonia, demam tifoid, shigellosis, leptospirosis, demam kambuhan yang ditularkan melalui kutu, pielonefritis, neurosifilis, dll.

-Servisitis, uretritis, dan konjungtivitis akibat Neisseria gonorrhoeae (dikombinasikan dengan pengobatan klamidia, kecuali pada neonatus), chancroid

SEDIAAN

1. Bubuk untuk injeksi, dalam botol 250 mg atau 1 g, untuk dilarutkan:

=dengan pelarut yang mengandung lidokain untuk injeksi IM saja. JANGAN MEMBERIKAN DENGAN INJEKSI ATAU INFUS IV larutan yang dilarutkan dengan pelarut ini.

=dengan air untuk injeksi untuk injeksi IV lambat (3 menit) atau infus (30 menit) dalam natrium klorida 0,9% atau glukosa 5%

IM

For intramuscular injection, dissolve Ceftriaxone Injection 0.5 g in 2 ml, and Ceftriaxone Injection 1 g in 3.5 ml lidocaine hydrochloride solutions 1% w/v and inject well within the body of a relatively large muscle. It is recommended not to inject more than 1 g at one site. Never administer the lidocaine solution intravenously.

IV

Intravenous injection

For intravenous injection, dissolve Ceftriaxone Injection 0.5 g in 5 ml, and Ceftriaxone Injection 1 g in 10 ml water for injections. The intravenous administration should be given over 2 to 4 minutes.

Intravenous dose for neonates, infants and children under 12 years of age should be given by infusion.

Intravenous infusion

The infusion should be given over at least 30 minutes. In neonates, intravenous dose should be given over 60 minutes to reduce the potential risk of bilirubin encephalopathy.

For intravenous infusion, dissolve Ceftriaxone Injection 2 g in 40 ml of one of the following calcium-free infusion solutions: sodium chloride 0.9%, sodium chloride 0.45% + dextrose 2.5%, dextrose 5%, dextrose10%, dextran 6% in dextrose 5%, hydroxyethyl starch 6 to 10%, water for injections. Ceftriaxone solutions may be incompatible with other medicines or diluents and should not be mixed with or piggybacked into solutions or diluents containing antibiotics or solutes different to those listed above.

The infusion line should be flushed after each administration.

Namun, terkadang Ringer Laktat (LR) atau cairan lain dipesan sebagai gantinya. Jangan memberikan ceftriaxone (Rocephin) dengan IV LR, karena dapat membentuk endapan yang dapat membahayakan pasien.